. Author manuscript; available in PMC: 2010 Sep 1.

Published in final edited form as: Synapse. 2009 Sep;63(9):717–728. doi: 10.1002/syn.20652

TABLE I.

Dissociation constants (K_d values) of [³H]WC-10 and [³H]raclopride binding to dopamine D₂ and D₃ receptors

Receptors	Radioligand
Receptors	[³H]WC-10^*	[³H]raclopride

hD_2L	76 ± 4	1.6 ± 0.1
hD₃	1.16 ± 0.1	18 ± 1
D_2L/D₃	65.5	0.09
rD_2L	158 ± 8.3	6.79 ± 0.6
rD₃	3.94 ± 0.19	17.1 ± 1.7
D_2L/D₃	40.1	0.4

K_d values (nM), presented as mean value ± S.E.M for n=3, were obtained through saturation binding of [³H]WC-10 and [³H]raclopride to a: cloned human D₃ and D_2L receptors expressed in HEK cells and b: rat D₃, D_2L receptors expressed in Sf9 cells.

Data were taken from Xu et. al., 2009