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Fractions of D2 and D3 receptors occupancy
| a1 | b1 | a2 | b2 | |
|---|---|---|---|---|
| Monkey | 0.05 | 0.78 | 0.86 | 0.36 |
| Rat | 0.02 | 0.5 | 0.6 | 0.37 |
a1, b1, a2, and b2 represents the receptors occupancy fractions of 4 nM [3H]WC-10 and 10 nM [3H]raclopride binding to dopamine D2 and D3 receptors in the monkey and rat striatum. These values were derived from the saturation binding isotherm, equation (2), using the Kd values in Table I.
