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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Cancer Res. 2009 Oct 6;69(21):8349–8355. doi: 10.1158/0008-5472.CAN-09-1669

Table 4.

Relativerisks (RR) of glioma in relation to BMI at specific ages.

Variable BMI category P for
trend
<18.5 18.5-24.9 25.0-29.9 30.0-34.9 35.0+
BMI at age 18 y
 No. of cases 26 175 24 11 0
 Age and sex adjusted RR 0.75 1.00 1.04 3.69 - 0.006
 95% CI 0.50, 1.13 ref 0.68, 1.60 2.01, 6.80 -
 Multivariate RR 1 0.69 1.00 1.04 3.74 - 0.003
 95% CI 0.45, 1.05 ref 0.67, 1.59 2.03, 6.90 -
 Mutually adjusted2 RR 0.68 1.00 1.05 3.91 - 0.003
 95% CI 0.45, 1.03 ref 0.68, 1.63 2.08, 7.35 -
BMI at age 35 y
 No. of cases 5 140 73 10 8
 Age and sex adjusted RR 0.82 1.00 1.19 1.05 3.82 0.01
 95% CI 0.34, 2.01 ref 0.89, 1.60 0.55, 2.01 1.87, 7.82
 Multivariate RR 0.72 1.00 1.19 1.07 4.05 0.01
 95% CI 0.29, 1.79 ref 0.89, 1.60 0.56, 2.05 1.97, 8.32
 Mutually adjusted3 RR 0.80 1.00 1.13 0.87 2.89 0.14
 95% CI 0.32, 2.00 ref 0.83, 1.54 0.43, 1.76 1.27, 6.56
BMI at age 50 y
 No. of cases 4 105 94 24 9
 Age and sex adjusted RR 0.95 1.00 0.97 1.09 1.38 0.51
 95% CI 0.35, 2.57 ref 0.73, 1.29 0.70, 1.71 0.70, 2.74
 Multivariate RR 0.86 1.00 0.99 1.11 1.46 0.41
 95% CI 0.31, 2.37 ref 0.74, 1.31 0.71, 1.75 0.73, 2.92
 Mutually adjusted3 RR 0.90 1.00 0.93 0.95 1.08 0.89
 95% CI 0.33, 2.47 ref 0.70, 1.25 0.59, 1.53 0.51, 2.25
Baseline BMI
 No. of cases 4 82 95 46 9
 Age and sex adjusted RR 1.85 1.00 0.90 1.27 0.71 0.92
 95% CI 0.68, 5.06 ref 0.67, 1.21 0.89, 1.83 0.35, 1.41
 Multivariate RR 1.66 1.00 0.90 1.29 0.74 0.95
 95% CI 0.59, 4.64 ref 0.67, 1.22 0.89, 1.86 0.37, 1.48
 Mutually adjusted3 RR 1.70 1.00 0.86 1.15 0.59 0.47
 95% CI 0.61, 4.76 ref 0.64, 1.17 0.78, 1.68 0.29, 1.21
1

Multivariate models are adjusted for age at baseline, age-squared, gender, race (White, Black, other), highest level of education (did not complete high school, completed high school, some college, completed college), and marital status (married, divorced, separated, widowed, unmarried). Models of BMI at age 18 y were additionally adjusted for height at age 18 (<1.60, 1.60-1.64, 1.65-1.69, 1.70-1.74, 1.75-1.79, 1.80-1.84, 1.85-1.90, 1.90+), and physical activity at age 18 (≤11.5, 11.6-26.5, 26.6-41.5, 41.6-51.5, 51.6+ MET-h per week). Models of BMI at age 35 y were adjusted for physical activity at age 35-39 and adult height. Models of BMI at age 50 y and baseline BMI were adjusted for physical activity during the past 10 y and adult height.

2

Additionally adjusted for baseline BMI.

3

Additionally adjusted for BMI at age 18.