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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Int J Cancer. 2010 Jan 1;126(1):256–265. doi: 10.1002/ijc.24765

Figure 4.

Figure 4

300 mg/kg EM011 fed daily does not cause any detectable pathologic abnormalities in normal tissues. A. Panels show H&E staining of paraffin-embedded tissue sections of the liver, kidney, spleen, duodenum, brain, heart, and lung, from vehicle-treated and EM011-treated mice (magnification, 200X). These tissues were indistinguishable between the EM011-treated and the control groups. The EM011-treated tumor microsections reveal large areas of tumor cell death, consistent with the therapeutic effects of EM011. However, microsections from vehicle-treated tumor tissue show sheets of tumor cells with high-grade pleomorphic nuclei with minimal cell death. EM011 does not cause any obvious hematologic toxicity. B. Bar-graph depicting no alterations in the CD4+, CD8+, B220+, and NK1.1+ cell counts from vehicle- and EM011- treated groups of mice as determined by flow cytometry-based immunophenotyping assays.