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. Author manuscript; available in PMC: 2010 Apr 22.
Published in final edited form as: Nature. 2009 Oct 22;461(7267):1122–1125. doi: 10.1038/nature08488

Figure 1. Brief sleep deprivation specifically impairs forms of LTP that depend on the cAMP/PKA pathway.

Figure 1

(a) The maintenance of spaced 4-train LTP was significantly disrupted in slices from sleep-deprived mice (p=0.03). (b) A similar deficit was observed in LTP induced by theta-burst stimulation (TBS) (p=0.003). (c) Massed 4-train LTP was unaffected in hippocampal slices from sleep-deprived mice (p=0.67). (d) 1-train LTP was unaffected in hippocampal slices from sleep-deprived mice (p=0.97).