Table 3.
Univariate Association of Each Covariate with Transition to Menopausal Stages
| Variable | Distinct Slopes | Common Slope | P Value* | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Stage Transition | Odds Ratio | 95% CI | P Value | Overall P Value | Odds Ratio | 95% CI | P Value | ||
| Age | Late Premenopausal | 1.05 | 1.02-1.09 | <0.001 | <0.001 | 1.11 | 1.09-1.13 | <0.001 | 0.001 |
| Early Transition | 1.12 | 1.08-1.16 | <0.001 | ||||||
| Late Transition | 1.19 | 1.14-1.25 | <0.001 | ||||||
| Post Menopausal | 1.14 | 1.06-1.23 | <0.000 | ||||||
| FSH | Late Premenopausal | 2.26 | 1.78- 2.88 | <0.001 | <0.001 | 2.56 | 2.27-2.89 | <0.001 | 0.536 |
| Early Transition | 2.92 | 2.26-3.77 | <0.001 | ||||||
| Late Transition | 2.66 | 2.15-3.28 | <0.001 | ||||||
| Post Menopausal | 2.41 | 1.79-3.23 | <0.001 | ||||||
| Inhibin B | Late Premenopausal | 1.74 | 1.49-2.02 | <0.001 | <0.001 | 0.54 | 0.49-0.59 | <0.001 | 0.075 |
| (decreasing) | Early Transition | 1.73 | 1.48-2.03 | <0.001 | |||||
| Late Transition | 2.38 | 1.94-2.92 | <0.001 | ||||||
| Post Menopausal | 1.90 | 1.20-3.00 | 0.006 | ||||||
| Estradiol | Late Premenopausal | 0.98 | 0.81-1.19 | 0.826 | 0.210 | 0.90 | 0.82-0.99 | 0.033 | 0.709 |
| Early Transition | 0.90 | 0.74-1.10 | 0.290 | ||||||
| Late Transition | 0.90 | 0.76-1.08 | 0.258 | ||||||
| Post Menopausal | 0.83 | 0.68-1.01 | 0.065 | ||||||
| Smoking | Late Premenopausal | 1.25 | 1.00-1.55 | 0.047 | 0.309 | 1.14 | 0.99-1.30 | 0.057 | 0.740 |
| Early Transition | 1.04 | 0.82-1.32 | 0.729 | ||||||
| Late Transition | 1.09 | 0.81-1.47 | 0.560 | ||||||
| Post Menopausal | 1.19 | 0.76-1.87 | 0.457 | ||||||
| Race (African American vs. Caucasian) | Late Premenopausal | 1.40 | 1.13- 1.74 | 0.002 | 0.018 | 1.07 | 0.94-1.22 | 0.312 | 0.012 |
| Early Transition | 0.89 | 0.71-1.13 | 0.349 | ||||||
| Late Transition | 0.85 | 0.63-1.13 | 0.259 | ||||||
| Post Menopausal | 1.10 | 0.72-1.68 | 0.665 | ||||||
| BMI | Late Premenopausal | 1.01 | 1.00- 1.03 | 0.041 | 0.027 | 1.00 | 0.99-1.01 | 0.980 | 0.012 |
| Early Transition | 1.00 | 0.99-1.02 | 0.862 | ||||||
| Late Transition | 0.98 | 0.97-1.01 | 0.167 | ||||||
| Post Menopausal | 0.96 | 0.94-0.99 | 0.034 | ||||||
| Alcohol | Late Premenopausal | 1.30 | 0.93-1.81 | 0.127 | 0.267 | 1.24 | 1.03-1.50 | 0.026 | 0.911 |
| Early Transition | 1.11 | 0.79-1.58 | 0.523 | ||||||
| Late Transition | 1.33 | 0.91-1.95 | 0.140 | ||||||
| Post Menopausal | 1.25 | 0.70-2.24 | 0.448 | ||||||
| Menarche | Late Premenopausal | 0.96 | 0.90-1.02 | 0.183 | 0.571 | 0.97 | 0.94-1.01 | 0.163 | 0.027 |
| Early Transition | 0.99 | 0.92-1.06 | 0.737 | ||||||
| Late Transition | 0.96 | 0.88-1.04 | 0.301 | ||||||
| Post Menopausal | 1.02 | 0.89-1.16 | 0.799 | ||||||
*
P value from the likelihood ratio test comparing common and distinct slopes.
Distinct slopes indicate the effect of the covariate at each menopausal stage. A significant common slope indicates the effect of the covariate is the same over all stages.