Table 8.
The symbols for each LOE in Table 7 are used in this table to show a concise overview of the ranking categories used for all LOEs. While an explicit definition of each each LOE is given in Table 9 (supplementary material), it is possible to derive the same definitions from the columns in this table. For example, the column for LOE-1 shows that the LOE for group “A” (Table 7) consists of the evidence types represented by two ranking categories (Table 6): pk-ct-pk and label-statement.
| Ranking category | LOE-1 | LOE-2 | LOE-3 | LOE-4 | LOE-5 |
|---|---|---|---|---|---|
| pk-ct-pk | A,B,C,G | ||||
| pk-ct-pk-genotype | D,E,F,O | ||||
| pk-ct-pk-phenotype | D,E,F,O | ||||
| pk-ddi-rndm | I,M,N | D,E,F,J | |||
| pk-ddi-non-rndm | I,N | D,E,F,J,M | |||
| iv-met-enz-id-Cyp-450-with-inh | G | D | |||
| iv-met-enz-id-Cyp-450-recombinant | K | ||||
| iv-met-enz-id-Cyp-450-microsomal | K | ||||
| iv-met-inh-recombinant | H,J,L | I | |||
| iv-met-inh-microsomal | H,J | I,L | |||
| label-statement | A,N | B,C,H,I,J,K,O | E,F,G,L,M | D | |
| nt-statement | N | K, | O | L,M | |
| obs-eval | N | ||||
| na-primary-total-clearance-enz | C | ||||
| na-primary-metabolic-clearance-enzyme | F | ||||
| na-substrate-of | G | D |