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In vitro drug sensitivity of Ba/F3 KIT502-3AYins single mutant. Sunitinib and dasatinib inhibited KIT kinase activity at ≤10 nM, inhibited cell proliferation with IC50s of 54 and 2.9 nM, and induced significant apoptosis at 100 and 10 nM respectively. Imatinib, nilotinib, and sorafenib inhibited KIT phosphorylation between 100-1000 nM, inhibited cell growth with IC50s of 517, 695 and 861 nM, respectively, and induced significant apoptosis at 1000 nM.
