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. Author manuscript; available in PMC: 2010 Nov 15.
Published in final edited form as: Clin Cancer Res. 2009 Oct 27;15(22):6862–6870. doi: 10.1158/1078-0432.CCR-09-1315

Table 1.

Comparative efficacy of TKI in BA/F3 KIT double mutants, harboring either a KIT exon 9 or exon 11 primary mutation

IC50s (nM)

Mutations Nilotinib Dasatinib Sorafenib
KIT502-503AY/V654A 1045 334.5 1672
KITV560del/V654A 192 585 1074

KIT502-503AY/D820Y 248 40.6 842
KITV559D/D820Y 297 432 944

KIT502-503AY/N822K 369 66.2 933

KITV560del/N822K NA NA NA