Table 1. Potential Anthrax Vaccine Strategies.
PA-based Vaccination Strategies |
First Generation (AVA) |
2nd Generation (PA102) |
3rd Generation (alternative rPA-based) |
Modified rPA |
Alternative adjuvants |
Needle-free delivery |
Intradermal injection |
Transcutaneous administration |
Mucosal administration |
Intranasal delivery |
Oral delivery (attenuated bacterial vector) |
Live, attenuated bacilli injection |
DNA vaccination |
Viral vector |
Plasmid injection |
Alternative vaccination strategies |
Bacilli capsular antigens |
Attenuated whole spores |
Spore antigens |
BclA |
BxpB |
other |
Passive antibody therapy |
Anti-PA |
Anti-LF |
Anti-capsule |
other |