Table 2.

Estradiol uniquely downregulates signaling pathways in activated SLE T cells but not in normal T cells. Gene lists that were generated from microarray data were analyzed for pathways uniquely downregulated in all SLE T cells and not in the control T cells. List shown is of pathways which met the criteria for significance (p ≤ 0.05) in SLE T cells.

Pathway	SLE T cells p-value	Control T cells p-value
PPARα/RXRγ Activation	0.0006	NS
G-Protein Coupled Receptor Signaling	0.0017	NS
Hepatic Fibrosis/Hepatic Stellate Cell Activation	0.0019	NS
cAMP-mediated Signaling	0.0024	NS
Nitrogen Metabolism	0.0058	NS
Propanoate Metabolism	0.0102	NS
Circadian Rhythm Signaling	0.0120	NS
Axonal Guidance Signaling	0.0174	NS
Keratan Sulfate Biosynthesis	0.0234	NS
Calcium Signaling	0.0275	NS
Fatty Acid Metabolism	0.0282	NS
Valine, Leucine and Isoleucine Degradation	0.0309	NS
Cardiac β2-adrenergic Signaling	0.0324	NS
β-alanine Metabolism	0.0417	NS
Phospholipid Degradation	0.0417	NS
Synaptic Long Term Potentiation	0.0437	NS
LPS/IL-1 Mediated Inhibition of RXR Function	0.0437	NS
TGF-β Signaling	0.0447	NS
IL-2 Signaling	0.0457	NS
Amyloid Processing	0.0457	NS