Table 3.

Estradiol uniquely upregulates signaling pathways in activated normal T cells but not in SLE T cells. Gene lists that were generated from microarray data were analyzed for pathways uniquely upregulated in all control but not in SLE T cells. List shown is of pathways which met the criteria for significance (p ≤ 0.05) in control T cells.

Pathway	Control T cells p-value	SLE T cells p-value
Axonal Guidance Signaling	0.0001	NS
Ephrin Receptor Signaling	0.0011	NS
Regulation of Actin-based Motility by Rho	0.0021	NS
Valine, Leucine and Isoleucine Degradation	0.0043	NS
Antigen Presentation Pathway	0.0102	NS
Sonic Hedgehog Signaling	0.0102	NS
Bile Acid Biosynthesis	0.0110	NS
Serotonin Receptor Signaling	0.0123	NS
N-Glycan Biosynthesis	0.0141	NS
Xenobiotic Metabolism Signaling	0.0191	NS
FXR/RXR Activation	0.0372	NS
β-alanine Metabolism	0.0407	NS
Aryl Hydrocarbon Receptor Signaling	0.0427	NS