Table 4.
Estradiol uniquely downregulates signaling pathways in activated control T cells but not in SLE T cells. Gene lists that were generated from microarray data were analyzed for pathways uniquely downregulated in all normal and not in the control T cells. List shown is of pathways which met the criteria for significance (p ≤ 0.05) in control T cells.
| Pathway | Control T cells p-value | SLE T cells p-value |
|---|---|---|
| IGF-1 Signaling | 0.0002 | NS |
| Insulin Receptor Signaling | 0.0002 | NS |
| PI3K/AKT Signaling | 0.0009 | NS |
| Natural Killer Cell Signaling | 0.0016 | NS |
| Fc Epsilon RI Signaling | 0.0017 | NS |
| Mitochondrial Dysfunction | 0.0025 | NS |
| Ceramide Signaling | 0.0030 | NS |
| Estrogen Receptor Signaling | 0.0039 | NS |
| NRF2-mediated Oxidative Stress Response | 0.0044 | NS |
| Synaptic Long Term Depression | 0.0056 | NS |
| Glucocorticoid Receptor Signaling | 0.0058 | NS |
| T Cell Receptor Signaling | 0.0091 | NS |
| Xenobiotic Metabolism Signaling | 0.0100 | NS |
| JAK/Stat Signaling | 0.0117 | NS |
| Oxidative Phosphorylation | 0.0126 | NS |
| VDR/RXR Activation | 0.0138 | NS |
| Integrin Signaling | 0.0145 | NS |
| Protein Ubiquitination Pathway | 0.0195 | NS |
| Neuregulin Signaling | 0.0200 | NS |
| Amyotrophic Lateral Sclerosis Signaling | 0.0234 | NS |
| Death Receptor Signaling | 0.0251 | NS |
| SAPK/JNK Signaling | 0.0282 | NS |
| Ubiquinone Biosynthesis | 0.0347 | NS |
| ERK/MAPK Signaling | 0.0398 | NS |
| FXR/RXR Activation | 0.0407 | NS |
| IL-4 Signaling | 0.0417 | NS |
| NF-κB Signaling | 0.0427 | NS |
| Apoptosis Signaling | 0.0437 | NS |