Table 5.
Estradiol differentially regulates expression of genes involved in the interferon-α pathway in SLE T cells. Data shown are the fold change (FC) in target gene expression from the same T cell sample cultured without and with estradiol.
| SLE | DRIP150 FC | IFIT1 FC | Controls | DRIP150 FC | IFIT1 FC | Rheumatoid Arthritis | DRIP150 FC | IFIT1 FC |
|---|---|---|---|---|---|---|---|---|
| SLE 1 | 1.11 | 0.80 | CTRL 1 | 1.06 | 1.19 | RA 1 | 1.18 | 0.93 |
| SLE 2 | 0.97 | CTRL 2 | 1.02 | 1.60 | RA 2 | 0.90 | 1.74 | |
| SLE 3 | 2.07 | 2.78 | CTRL 3 | 1.71 | 1.09 | RA 3 | 1.22 | 2.92 |
| SLE 4 | 16.57 | 0.01 | CTRL 4 | 0.62 | 0.05 | RA 4 | 0.46 | 0.93 |
| SLE 5 | 18.89 | 0.20 | CTRL 5 | 1.25 | 0.72 | RA 5 | 0.49 | 0.89 |
| SLE 6 | 1.08 | 2.22 | CTRL 6 | 0.63 | 0.74 | |||
| SLE 7 | 15.27 | ND | CTRL 7 | 0.74 | 1.25 | |||
| SLE 8 | 0.34 | 0.59 | CTRL 8 | 1.80 | 2.34 | |||
| SLE 9 | 3.22 | 1.93 | CTRL 9 | 0.97 | 2.08 | |||
| SLE 10 | 8.03 | 0.88 | CTRL 10 | 1.06 | 0.74 | |||
| SLE 11 | ND | 5.15 | ||||||
| SLE 12 | ND | 6.60 | ||||||
| Mean FC: | 6.75 | 2.12 | Mean FC: | 1.09 | 1.18 | Mean FC: | 0.85 | 1.48 |
| Median FC: | 2.65 | 1.41 | Median FC: | 1.04 | 1.14 | Median FC: | 0.90 | 0.93 |
| Std. Dev.: | 7.38 | 2.20 | Std. Dev.: | 0.41 | 0.68 | Std. Dev.: | 0.36 | 0.88 |
ND = not done.