Table 3.
Library data for compounds 26{1–38}.
| compound | alcohol | acid derivative | yielda (%) | purityc (%) |
|---|---|---|---|---|
| 26{1} | 22{1} | 23{1} | 71b | >99 |
| 26{2} | 22{1} | 23{2} | 82b | 97 |
| 26{3} | 22{1} | 23{3} | 69b | 96 |
| 26{4} | 22{1} | 23{4} | 44b | 96 |
| 26{5} | 22{1} | 23{6} | 55b | >99 |
| 26{6} | 22{1} | 23{8} | 50 | >99 |
| 26{7} | 22{1} | 23{9} | 27 | >99 |
| 26{8} | 22{1} | 23{10} | 21 | >99 |
| 26{9} | 22{1} | 23{11} | 38 | >99 |
| 26{10} | 22{1} | 23{12} | 35 | 91 |
| 26{11} | 22{1} | 23{13} | 66 | >99 |
| 26{12} | 22{2} | 23{1} | 55 | 97 |
| 26{13} | 22{2} | 23{2} | 76 | 97 |
| 26{14} | 22{2} | 23{3} | 67 | >99 |
| 26{15} | 22{2} | 23{4} | 49 | 97 |
| 26{16} | 22{2} | 23{5} | 35 | 94 |
| 26{17} | 22{2} | 23{6} | 48 | >99 |
| 26{18} | 22{2} | 23{7} | 23 | >99 |
| 26{19} | 22{2} | 23{8} | 51 | >99 |
| 26{20} | 22{2} | 23{11} | 66 | >99 |
| 26{21} | 22{2} | 23{12} | 18 | >99 |
| 26{22} | 22{2} | 23{13} | 69 | >99 |
| 26{23} | 22{2} | 23{14} | 49 | >99 |
| 26{24} | 22{2} | 23{15} | 47 | >99 |
| 26{25} | 22{1} | 24{1} | 31 | >99 |
| 26{26} | 22{1} | 24{2} | 34 | >99 |
| 26{27} | 22{1} | 24{3} | 59 | >99 |
| 26{28} | 22{1} | 24{4} | 43 | 99 |
| 26{29} | 22{2} | 24{1} | 50 | >99 |
| 26{30} | 22{2} | 24{2} | 61 | >99 |
| 26{31} | 22{2} | 24{3} | 67 | >99 |
| 26{32} | 22{1} | 25{1} | 39 | >99 |
| 26{33} | 22{1} | 25{2} | 13 | 98 |
| 26{34} | 22{1} | 25{4} | 22 | >99 |
| 26{35} | 22{2} | 25{1} | 34 | >99 |
| 26{36} | 22{2} | 25{2} | 35 | 97 |
| 26{37} | 22{2} | 25{3} | 42 | 99 |
| 26{38} | 22{2} | 25{4} | 42 | 96 |
a
Isolated yield after preparative HPLC.
b
Isolated yield after column chromatography.
c
UV purity determined at 214 nm after preparative HPLC.