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. Author manuscript; available in PMC: 2010 Dec 25.
Published in final edited form as: Neurosci Lett. 2009 Oct 12;467(2):150–154. doi: 10.1016/j.neulet.2009.10.027

Figure 1.

Figure 1

Group mean activity (± SEM) of L6-S1 dorsal horn neurons excited by urinary bladder distension (UBD) measured two hours after treatment with intravesical zymosan (top panel- inflamed bladder), intravesical saline (middle panel - procedure control) or subcutaneous zymosan (bottom panel – nonspecific action control). Activity was quantified as an Evoked Response produced by 20s of the indicated intensity of UBD and was normalized for each neuron as a percentage of the activity evoked by a 60 mm Hg, 20 s UBD measured 2 hrs previously. Neurons were stratified according to the effect of heterosegmental noxious conditioning stimuli (HNCS): Type I neurons were inhibited by HNCS and Type II neurons were not inhibited by HNCS. There was a differential effect of zymosan on Type I versus Type II neurons with a robust increase in Evoked Responses of Type II neurons but no statistically significant effect of intravesical zymosan on the Type I neurons. There was no statistically significant effect of the intravesical saline or the subcutaneous zymosan treatments in either Type I or Type II neurons. * indicates significant difference from baseline measurement, p<0.05.