Skip to main content
. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Gynecol Oncol. 2009 Oct 4;115(3):438–442. doi: 10.1016/j.ygyno.2009.09.007

Fig. 3. Sensitization to TRAIL and TNFα by SHetA2 is due to apoptosis.

Fig. 3

A2780 (A) and SK-OV-3 (B) ovarian cancer cell cultures or primary normal endometrial cultures (C) were treated with indicated doses of SHetA2 in the presence or absence of the indicated concentrations of TNFα or TRAIL for the time indicated in A and C, and for 24 hours in B. The percent of cells undergoing apoptosis at the end of the treatment period was evaluated by flow cytometric analysis of Annexin-V/ PI staining of the cells. Two tailed t-tests were performed on percent apoptosis in cultures treated with SHetA2 only in comparison to SHetA2 combined with TNFα or TRAIL: A) 24 hr p value <0.0001, 30 hr p=0.0002, 48 hr p=0.0005; B) p values are depicted within the figure, and C) p>0.05 for all comparisons.