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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: Trends Biochem Sci. 2009 Oct 7;34(11):562–570. doi: 10.1016/j.tibs.2009.07.002

Figure 2. Schematic comparison of CUL4 proteins and mouse Cul4A mutants.

Figure 2

A. Human cells contain two CUL4 genes encoding CUL4A (NP_001008895) and two isoforms of CUL4B (NP_001073341 and NP_003579.3) proteins which differ by only 22 amino acids at the N-terminus.

B. Wild type mouse Cul4A gene and comparison of three targeted Cul4A mutants. Filled and open boxes denote coding and non-coding exons, respectively. Exons encoding the DDB1 and ROC 1 binding regions in CUL4A have been noted. Three mouse models targeting Cul4A have been generated to date, deleting exon 1, exons 4-8, and exons 17-19, respectively. Discrepancies in reported phenotypes might be due to unintentional disruption of a nearby neighboring gene, Pcid2.