Table 1.
Patterns of Psychopathology in ADHD Siblings and Their Parents.
| Lifetime Diagnosis* | CBCL Profiles | Pathology in One or Both Parents by Child CBCL-PBD Status** | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls (n=392) |
↑PBD (n=45) |
↑AP (n=103) |
Total (n=540) |
Effect | No PBD (n=228) |
≥ 1 PBD (n=42) |
Total (n=270) |
Effect | |||
| n (%) | n (%) | n (%) | n (%) | Statistic | p value | n (%) | n (%) | n (%) | Statistic | p value | |
| ADHD | 138 (61) | 25 (60) | 163 (60) | Χ2=.02 | .9 | ||||||
| Conduct Disorder | 36 (9) | 11 (24) | 5 (5) | 52 (10) | G2=11.7 | .003 | 38 (17) | 7 (17) | 45 (17) | Χ2=0 | 1.00 |
| Dysthymia | 23 (6) | 4 (9) | 3 (3) | 30 (6) | G2=2.5 | .3 | 41 (18) | 12 (29) | 53 (20) | Χ2=2.5 | .1 |
| Generalized Anxiety | 57 (15) | 15 (33) | 9 (9) | 81 (15) | Χ2=15.1 | .001 | 34 (15) | 6 (14) | 40 (15) | Χ2=.01 | .9 |
| Major Depression | 62 (16) | 9 (20) | 15 (15) | 86 (16) | Χ2=.7 | .7 | 154 (68) | 29 (69) | 183 (68) | Χ2=.04 | .8 |
| OCD | 20 (5) | 7 (16) | 9 (9) | 36 (7) | G2=6.6 | .02 | 12 (5) | 5 (15) | 17 (6) | G2=3.9 | .05 |
| ODD | 183 (47) | 31 (69) | 43 (42) | 257 (48) | Χ2=9.7 | .008 | 28 (12) | 9 (21) | 37 (14) | Χ2=2.5 | .1 |
| PTSD | 13 (3) | 0 (0) | 1 (1) | 14 (3) | G2=4.5 | .1 | 36 (16) | 10 (24) | 46 (17) | Χ2=1.6 | .2 |
| Substance Abuse | 11 (3) | 1 (2) | 0 (0) | 12 (2) | G2=5.2 | .07 | 88 (39) | 26 (62) | 114 (42) | Χ2=7.9 | .005 |
| Substance Depend | 2 (.5) | 0 (0) | 0 (0) | 2 (.4) | G2=1.28 | .5 | 57 (25) | 15 (36) | 72 (27) | Χ2=2.1 | .1 |
| Tourette’s Disorder | 15 (4) | 5 (11) | 9 (9) | 29 (5) | G2=6.3 | .04 | 3 (1) | 1 (2) | 4 (2) | Χ2=2.1 | .1 |
CBCL - Child Behavior Checklist; PBD - CBCL Pediatric Bipolar Disorder Scale; AP - CBCL Attention Problem Scale; ADHD - Attention Deficit/Hyperactivity Disorder; OCD - Obsessive Compulsive Disorder; ODD - Oppositional Defiant Disorder; PTSD - Post Traumatic Stress Disorder
*
Includes all categories occurring in > 5% probands or parents.
**
Parent CBCL-PBD status based on having ≥ 1 child meeting CBCL-PBD criteria. G2 – Fisher’s Exact Test.