Table 1.
High-level amplifications in lung and esophageal squamous cell carcinomas
| Lung Squamous Cell Carcinoma Amplifications | ||||
|---|---|---|---|---|
| Cytoband | q value | Peak Boundaries | Genes in Peak | Candidate Target(s) |
| 3q26.33 | 4.8E-21 | 182.29–184.44 | 4 | SOX2 |
| 8p12 | 1.5E-07 | 38.25–39.72 | 10 | FGFR1, WHSC1L1 |
| 7p11.2 | 5.2E-06 | 54.31–55.74 | 7 | EGFR |
| Esophageal Squamous Cell Carcinoma Amplifications | ||||
| Cytoband | q value | Peak Boundaries | Genes in Peak | Candidate Target(s) |
| 11q13.3 | 4.1E-41 | 68.81–69.94 | 10 | CCND1 |
| 7p11.2 | 6.3E-06 | 54.60–55.36 | 2 | EGFR |
| 3q26.33 | 6.0E-06 | 182.71–183.93 | 1 | SOX2 |
| 8q24.21 | 0.003 | 128.35–128.70 | 2 | MYC, POU5F1B |
| 8p12 | 0.003 | 38.23–38.76 | 6 | FGFR1, WHSC1L1, PPADC1B |
GISTIC-defined peaks of high-level (inferred copy-number >3.6) recurrent genomic amplification in lung squamous cell carcinoma and esophageal squamous cell carcinoma.