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. Author manuscript; available in PMC: 2010 Dec 29.
Published in final edited form as: Neuroscience. 2009 Sep 22;164(4):1776–1793. doi: 10.1016/j.neuroscience.2009.09.028

Figure 2.

Figure 2

Monophasic inward current to 5-HT unmasked by the 5-HT1A antagonist, WAY 100635 in BNSTALG neurons that initially exhibited a 5-HTHyp-Dep response to 5-HT. A, Application of 5-HT1A antagonist WAY 100635 (200 nM) unmasked an inward current. B, Ramp traces showing the shift of E5-HT to more depolarized level of −42 mV when 5-HT was applied in the presence of WAY 100635, which suggested the activation of a non-selective cation current. C, Histographs showing the inward currents elicited by 5-HT in the control condition (9.8 ± 2.6 pA, n = 9) and in the presence of WAY 100635 (11.9 ± 2.3 pA, n = 9). D, In the presence of WAY 100635, E5-HT was significantly shifted from the control at −71.4 ± 2.9 mV to −43.2 ± 2.4 mV, n=9. **, paired t-test, p<0.01.