Table 2. Summary of the global gene p-values, permutation test, and False Disvory Rate for all genes with a permutation p ≤ 0.05.
Gene | # SNPs | p-value for most signifcant SNP* | permutation p - value for gene* | False Discovery Rate |
---|---|---|---|---|
PTEN | 2 | <0.0001 | 0.0001 | 0.019 |
POLB | 3 | 0.00010 | 0.00040 | 0.076 |
ARNT | 9 | 0.00040 | 0.0018 | 0.22 |
IFNGR1 | 2 | 0.0023 | 0.0070 | 0.58 |
RGS5 | 1 | 0.0073 | 0.0092 | 0.58 |
ROS1 | 7 | 0.0012 | 0.0098 | 0.58 |
MX1 | 7 | 0.0020 | 0.015 | 0.58 |
AMACR | 6 | 0.0026 | 0.016 | 0.58 |
CFH | 5 | 0.0042 | 0.020 | 0.58 |
IL12A | 1 | 0.018 | 0.022 | 0.58 |
TERF1 | 5 | 0.0052 | 0.026 | 0.58 |
SLC23A1 | 3 | 0.0084 | 0.027 | 0.58 |
BAX | 1 | 0.027 | 0.031 | 0.58 |
NQO1 | 2 | 0.026 | 0.031 | 0.58 |
PARP1 | 6 | 0.0064 | 0.032 | 0.58 |
MBL2 | 9 | 0.0037 | 0.033 | 0.58 |
LIPC | 10 | 0.0035 | 0.036 | 0.58 |
CAV1 | 3 | 0.012 | 0.041 | 0.58 |
SCUBE2 | 3 | 0.013 | 0.044 | 0.58 |
ESR1 | 6 | 0.0072 | 0.047 | 0.58 |
PLK1 | 1 | 0.043 | 0.047 | 0.58 |
XRCC3 | 2 | 0.023 | 0.048 | 0.58 |
Adjusted for age (<55 years, ≥55 years), sex, smoking (0 pack-years, 0< pack-years <25, ≥25 pack-years), and lifetime coal use (<130 tons, ≥130 tons)