Table 3. PTEN polymorphisms and COPD risk.
| SNP | Genotype | Cases | Controls | OR* | 95% CI* | p |
|---|---|---|---|---|---|---|
| rs701848 | CC | 31 | 29 | |||
| CT | 19 | 53 | 0.31 | 0.14-0.67 | 0.0030 | |
| TT | 3 | 22 | 0.12 | 0.03-0.47 | 0.0020 | |
| CT + TT | 22 | 75 | 0.25 | 0.12-0.53 | 0.00026 | |
| trend | 0.00021 | |||||
| rs1903858 | GG | 24 | 22 | |||
| AG | 23 | 55 | 0.32 | 0.14-0.71 | 0.0054 | |
| AA | 4 | 20 | 0.13 | 0.04-0.44 | 0.0010 | |
| AG + AA | 27 | 84 | 0.25 | 0.12-0.55 | 0.00055 | |
| trend | 0.00031 |
*
Odds ratios (OR) and 95% confidence intervals (CI) are adjusted for age (<55 years, ≥55 years), sex, smoking (0 pack-years, 0< pack-years <25, ≥25 pack-years), and lifetime coal use(<130 tons, ≥130 tons).