Table 4. PTEN polymorphisms and COPD risk, by smoking status.
Non-smokers | <25 pack-years | ≥25 pack-years | |||
---|---|---|---|---|---|
SNP | Genotype | OR (95% CI)* | OR (95% CI)* | OR (95% CI)* | p-interaction |
rs701848 | GG | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |
GA+AA | 0.40 (0.13-1.23) | 0.14 (0.01-1.43) | 0.15 (0.04-0.51) | 0.24 | |
rs1903858 | AA | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | |
AG+GG | 0.38 (0.11-1.26) | 0.36 (0.05-2.52) | 0.15 (0.04-0.55) | 0.35 |
Odds ratios (OR) and 95% confidence intervals (CI) are adjusted for age (<55 years, ≥55 years), sex, and lifetime coal use(<130 tons, ≥130 tons).