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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Respir Med. 2009 Jul 21;103(12):1866–1870. doi: 10.1016/j.rmed.2009.06.016

Table 4. PTEN polymorphisms and COPD risk, by smoking status.

Non-smokers <25 pack-years ≥25 pack-years
SNP Genotype OR (95% CI)* OR (95% CI)* OR (95% CI)* p-interaction
rs701848 GG 1.00 (reference) 1.00 (reference) 1.00 (reference)
GA+AA 0.40 (0.13-1.23) 0.14 (0.01-1.43) 0.15 (0.04-0.51) 0.24
rs1903858 AA 1.00 (reference) 1.00 (reference) 1.00 (reference)
AG+GG 0.38 (0.11-1.26) 0.36 (0.05-2.52) 0.15 (0.04-0.55) 0.35
*

Odds ratios (OR) and 95% confidence intervals (CI) are adjusted for age (<55 years, ≥55 years), sex, and lifetime coal use(<130 tons, ≥130 tons).