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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: J Biomed Inform. 2009 May 10;42(6):979–989. doi: 10.1016/j.jbi.2009.05.001

Table 1.

The evidence board used only one-third of the 36 types in the evidence taxonomy to classify all the 257 non-redundant evidence items. The 12 evidence types are shown in this table along with the number of supporting or refuting evidence items each type was assigned to. Indented evidence types are sub-types of the type in the previous row

Clinical trial types

Evidence type Evidence for Evidence against

A pharmacokinetic clinical trial 31 0
 A genotyped pharmacokinetic clinical trial 5 1
A randomized DDI clinical trial 49 11
A non-randomized DDI clinical trial 8 0
 A parallel groups DDI clinical trial 4 0

Total 97 12
in vitro experiment types

Evidence type Evidence for Evidence against

A CYP450, recombinant, metabolic enzyme inhibition experiment 2 0
A CYP450, human microsome, metabolic enzyme inhibition experiment 13 2
A drug metabolism identification experiment 4 0
 A CYP450, recombinant, drug metabolism identification experiment with possibly NO probe enzyme inhibitor(s) 31 6
 A CYP450, human microsome, drug metabolism identification experiment using chemical inhibitors 8 4

Total 58 12
Non-traceable statement types

Evidence type Evidence for Evidence against

A non-traceable, but possibly authoritative, statement 22 0
 A non-traceable drug-label statement 52 4

Total 74 4