Table 1.
The evidence board used only one-third of the 36 types in the evidence taxonomy to classify all the 257 non-redundant evidence items. The 12 evidence types are shown in this table along with the number of supporting or refuting evidence items each type was assigned to. Indented evidence types are sub-types of the type in the previous row
Clinical trial types | ||
---|---|---|
Evidence type | Evidence for | Evidence against |
A pharmacokinetic clinical trial | 31 | 0 |
A genotyped pharmacokinetic clinical trial | 5 | 1 |
A randomized DDI clinical trial | 49 | 11 |
A non-randomized DDI clinical trial | 8 | 0 |
A parallel groups DDI clinical trial | 4 | 0 |
| ||
Total | 97 | 12 |
in vitro experiment types | ||
| ||
Evidence type | Evidence for | Evidence against |
| ||
A CYP450, recombinant, metabolic enzyme inhibition experiment | 2 | 0 |
A CYP450, human microsome, metabolic enzyme inhibition experiment | 13 | 2 |
A drug metabolism identification experiment | 4 | 0 |
A CYP450, recombinant, drug metabolism identification experiment with possibly NO probe enzyme inhibitor(s) | 31 | 6 |
A CYP450, human microsome, drug metabolism identification experiment using chemical inhibitors | 8 | 4 |
| ||
Total | 58 | 12 |
Non-traceable statement types | ||
| ||
Evidence type | Evidence for | Evidence against |
| ||
A non-traceable, but possibly authoritative, statement | 22 | 0 |
A non-traceable drug-label statement | 52 | 4 |
| ||
Total | 74 | 4 |