. Author manuscript; available in PMC: 2010 Nov 12.

Published in final edited form as: J Med Chem. 2009 Nov 12;52(21):6931–6935. doi: 10.1021/jm900823s

Table 1. IC50 inhibition values of several phenoxyauxins and fibrates on the sweet-sensing receptor.

IC50 values of the tested compounds were determined from the calcium mobilization assays with heterologously expressed human T1R2+T1R3 receptor activated by 2.5mM sucralose in the presence of increasing concentrations of inhibitors. IC50s are means ± SD from at least 3 independent experiments.

compound	IC50	µM(SD)
Lactisole	70	(13)

IPA	>1000
IAA	>1000
IBA	>1000
PAA	>500
NAA	233	(82)
4-CPA	142	(19)
2,4D	50	(10)
2,4DP	5.3	(1.3)
2,4,5TPP	5.7	(1.2)
MCPP	12	(3)

Clofibric acid	28	(8)
Gemfibrozil	69	(20)
Bezafibric acid	100	(11)