Table 2.

Age and Multivariate Adjusted Hazard Ratios (HR) and 95% CIs for Incident Cerebrovascular Disease by Categories of Periodontitis

	Median	Median # teeth	Events	IR*	HR (95% CI)†	HR (95% CI)‡	HR (95% CI)§
Mean bone loss score (Schei)
≤ 0.5	0.25	26	10	94	1.00	1.00	1.00
>0.5 – ≤ 1	0.74	24	22	269	1.83	1.88	1.70
					(0.85, 3.90)	(0.88, 4.03)	(0.79, 3.65)
>1 – ≤ 1.5	1.22	22	24	468	2.58	2.74	2.28
					(1.20, 5.56)	(1.27, 5.92)	(1.05, 4.96)
> 1.5	1.85	17	24	758	3.98	4.48	3.52
					(1.83, 8.63)	(2.05, 9.80)	(1.59, 7.81)
Continuous‖	0.67	24	80	296	1.88	2.06	1.85
					(1.40, 2.53)	(1.51, 2.81)	(1.33, 2.58)
Test of trend					<0.001	<0.001	0.001
Cumulative Probing depth
0 – ≤ 4	0	24	22	241	1.00	1.00	1.00
> 4 – ≤ 30	16	24	31	291	0.92	0.92	0.89
					(0.53, 1.60)	(0.53, 1.61)	(0.51, 1.56)
>30	48	25	26	383	1.18	1.20	1.07
					(0.66, 2.10)	(0.67, 2.15)	(0.59, 1.93)
Continuous#	12	24	79	298	1.09	1.10	1.07
					(0.92, 1.28)	(0.93, 1.30)	(0.90, 1.27)
Test of trend					0.46	0.42	0.71

^*Crude incidence rate (IR) for cerebrovascular disease (cases/10⁵ person-years)

^†Age adjusted estimates

^‡Adjusted for age, marital status, and baseline measures of education, occupation and income.

^§Adjusted for age, BMI, HDL, total cholesterol, triglycerides, diagnosis of hypertension, mean systolic blood pressure, mean diastolic blood pressure, diabetes diagnosis, daily alcohol consumption, comprehensive smoking index, marital status, and baseline measures of education, occupation and income.

^‖HR for increase in mean bone loss score by one

^#HR for 20mm increase in cumulative probing depth