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. Author manuscript; available in PMC: 2010 May 1.
Published in final edited form as: Gene Ther. 2009 Jul 30;16(11):1300–1313. doi: 10.1038/gt.2009.93

Figure 3. IL-12 produced by activated B cells does not affect T cell proliferation in vitro.

Figure 3

(A, B) B cells were either not stimulated or stimulated with indicated agents for 20 hrs and the levels of released IL-12p70 (A) or IL-10 (B) were determined. One of three similar experiments is shown. (C) Proliferation of OT-1 cells incubated with fresh (Med) or activated (CpG + α-CD40) irradiated OVA-transgenic B cells in the absence or presence of IL-12-specific neutralizing antibodies (5 μg/ml). (D) IFN-γ production by OT-1 or OT-2 T cells incubated for 20 hrs with fresh or activated irradiated OVA-transgenic B cells at 1:2 B:T cell ratio. One of two experiments is shown; error bars represent SE.