Table 1.
Patients | 25 |
Sex, male/female | 15/10 |
Gestational age at birth, weeks | 28 (23 - 41) |
Etiology of chronic lung disease, (%) | |
Bronchopulmonary dysplasia | 18 (72%) |
Congenital diaphragmatic hernia | 3 (12%) |
Persistent pulmonary hypertension of the newborn | 3 (12%) |
Pulmonary hypoplasia | 1 (4%) |
Age at initiation of sildenafil, days | 171 (14 - 673) |
Respiratory support at initiation of sildenafil, (%) | |
Oxygen | 25 (100%) |
CPAP | 1 (4%) |
Mechanical ventilation | 18 (72%) |
ECMO | 1 (4%) |
Medications at initiation of sildenafil, (%) | |
Nitric Oxide | 18 (72%) |
Calcium Channel Blocker† | 1 (4%) |
Bosentan | 2 (8%) |
Milrinone | 4 (16%) |
Diuretics | 19 (76%) |
Systemic steroids | 12 (48%) |
CPAP = continuous positive airway pressure; ECMO = extracorporeal membrane oxygenation.
Values are median (range) unless otherwise noted.
For systemic hypertension.