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. Author manuscript; available in PMC: 2010 Nov 1.
Published in final edited form as: J Acquir Immune Defic Syndr. 2009 Nov 1;52(3):336–341. doi: 10.1097/QAI.0b013e3181b628be

Table 1. Composite Variables for Reasons to Discontinue or Change ARVs.

Composite Variable Reasons for Discontinuation/Change of ARVs given by Provider
Virologic failure Failure/viremia, documented resistance, therapy intensification
Poor adherence Self discontinued, poor adherence, therapy simplification, self administration of regimen taken in the past
Toxicities
 GI related Nausea/vomiting, diarrhea, pancreatitis, hepatitis/liver failure, lactic acidosis, abdominal pain, constipation, anorexia, belching, abdominal bloating, difficulty swallowing, GI bleeding, rectal bleeding
 Neurologic/non-psychiatric Headache, sedation, insomnia, stumbling gait, peripheral neuropathy, dizziness/vertigo
 Constitutional Arthralgias, fever/chills, cough, weight loss/cachexia, fatigue, malaise/lethargy, myalgias/muscle pain, edema, night sweats, back/flank pain, lymphadenopathy, chest pain, asthenia/weakness
 CNS related/Psychiatric Hypomania, anxiety/stress, depression, vivid dreams, altered mental status/delirium, mental disorder
 GU related Renal failure, nephrolithiasis, proteinuria, urinary dysfunction
 Metabolic/Endocrine Lipodistrophy, fat redistribution, increased lipids, increased glucose, breast enlargement, hypophosphatemia
 Dermatologic Rash, injection site itching/nodules, alopecia, angioedema, flushing
 Hematologic Anemia, leucopenia/neutropenia
Other medical condition/drug interaction Pneumonia, hospitalized, improving from previous medical condition caused by drugs, drug abuse/substance abuse, myocardial infarction, upper respiratory infection, erectile dysfunction, concomitant illness, congestive heart failure, meningitis, pregnancy, delivery of child