Table 1. Comparison of estrogen metabolism in Wildtype and HPV Transgenic mice with and without 2000ppm DIM in the diet.
| E1 | E2 | 2OHE1 | 16OHE1 | 4OHE1 | E3 | C2/C16 Ratio | ||
|---|---|---|---|---|---|---|---|---|
| Wildtype | ||||||||
| n=9 | Mean | 4.7 | 0.8 | 0.9 | 1.9 | 0.0 | 1.5 | 0.5 |
| SD | 5.0 | 0.5 | 1.0 | 1.5 | 0.1 | 1.5 | ||
| Wildtype with DIM | * | |||||||
| n=7 | Mean | 4.8 | 0.2 | 3.2 | 1.1 | 0.0 | 0.1 | 2.8 |
| SD | 4.3 | 0.2 | 3.7 | 1.0 | 0.0 | 0.3 | ||
| Transgenic | ||||||||
| n=10 | Mean | 3.6 | 0.3 | 0.3 | 1.3 | 0.0 | 0.7 | 0.2 |
| SD | 4.2 | 0.3 | 0.3 | 0.9 | 0.0 | 0.7 | ||
| Transgenic with DIM | * | |||||||
| n=10 | Mean | 1.0 | 1.6 | 1.0 | 0.9 | 0.0 | 0.9 | 1.1 |
| SD | 1.2 | 2.6 | 1.1 | 1.1 | 0.1 | 1.0 | ||
DIM increased C-2 hydroxylation of estradiol in both the wildtype mouse and in the HPV transgenic mouse by 28%, (p< 0.05) and 33%, (p<0.05) respectively.