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. Author manuscript; available in PMC: 2010 May 1.

Published in final edited form as: Cancer Res. 2009 Oct 20;69(21):8231–8235. doi: 10.1158/0008-5472.CAN-09-2543

Characterization of uterine tumors in mice with conditional deletion of p53 and/or Brca1 using Amhr2-driven Cre recombinase. A) Kaplan-Meier survival curves for Amhr2^Cre/+/Brca1^lox/lox, Amhr2^Cre/+/p53^lox/lox and Amhr2^Cre/+/p53^lox/lox/Brca1^lox/lox mice. B) Uterine tumors in Amhr2^Cre/+/p53^lox/lox (Tumor 1) and Amhr2^Cre/+/p53^lox/lox/Brca1^lox/lox mice (Tumor 2). C) Detection of Cre-mediated recombination of p53 in tumors dissected from an Amhr2^Cre/+/p53^lox/lox mouse (Tumor 1) and double recombination of p53 and Brca1 in a tumor dissected from an Amhr2^Cre/+/p53^lox/lox/Brca1^lox/lox mouse (Tumor 2). Tail tissue from the Amhr2^Cre/+/p53^lox/lox/Brca1^lox/lox mouse was used as a control.