Skip to main content
. Author manuscript; available in PMC: 2010 Nov 4.
Published in final edited form as: J Am Chem Soc. 2009 Nov 4;131(43):15909–15917. doi: 10.1021/ja906801g

Scheme 7.

Scheme 7

Synthesis of Carboxylic Acid (+)-4 via Conjugate Additiona

aReagents and conditions: a) tert-butyl acrylate (2.0 equiv), KOt-Bu (1.0 M in t-BuOH, 2.0 equiv), THF, 25 °C, 30 min, 92% (ca. 2:1 dr); b) LiOH (1 N aqueous):MeOH (1:1), 50 °C, 6 h, 97%.