Table I.
Enrolled/Evaluable: | 50/45 | |
Median (range) Age [yrs]: | 8 (2.5–17) | |
Male/Female: | 27/23 | |
Diagnosis: | Neuroblastoma | 46 |
Ganglioneuroblastoma | 4 | |
Prior Therapy: | ≥ chemotherapy regimens | 25 |
<3 chemotherapy regimens | 25 | |
131I MIBG | 26 | |
Biologic Therapy | 44 | |
HSCT | 39 | |
Radiation Therapy | 41 | |
Disease Status at Enrollment: | Measurable | 9 |
Evaluable | 33 | |
No Evidence of Disease | 8 | |
ABT-751 Dosing Schedule: | Daily × 7d every 21d | 8 |
Daily × 21d every 28d | 9 | |
Expansion cohort | 33 | |
ABT-751 cycles: median (range) | 4 (1–53) |