. Author manuscript; available in PMC: 2011 Jan 1.

Published in final edited form as: Pediatr Blood Cancer. 2010 Jan;54(1):47–54. doi: 10.1002/pbc.22267

Table II.

Cytotoxicity of ABT-751 and Vincristine in Pediatric Solid Tumor Cell Lines

Cell Line	Lineage	Assay	Vincristine		ABT-751
Cell Line	Lineage	Assay	IC₅₀ (mcM)	h	IC₅₀ (mcM)	h
RD	Rhabdomyosarcoma	SRB	0.0030	1.5	3.1	1.8
		ACEA	0.0073	1.7	4.6	1.1

TC-71	Ewing sarcoma	SRB	0.0069	1.6	1.1	6.0
		ACEA	0.0023	1.6	1.4	10.9

LD	Ewing sarcoma	SRB	0.0019	2.0	0.68	3.5
		ACEA	0.0012	7.6	0.85	6.1

HTB-186	Medulloblastoma	SRB	0.0025	2.0	2.6	0.66
		ACEA	0.0039	2.7	1.2	4.0

HOS	Osteosarcoma	SRB	0.0072	1.6	1.4	4.3
		ACEA	0.0088	4.0	3.8	4.2

SK-N-AS	Neuroblastoma	SRB	0.0041	0.80	0.61	3.3
		ACEA	0.0048	1.4	0.91	10.5

SK-N-DZ	Neuroblastoma	SRB	0.0029	0.78	1.2	2.7
		ACEA	0.0013	5.8	2.6	2.9

KCNR	Neuroblastoma	SRB	0.0018	2.8	0.98	2.5
		ACEA	0.0017	1.4	1.0	20.7