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. Author manuscript; available in PMC: 2010 Dec 1.
Published in final edited form as: Bioorg Med Chem Lett. 2009 Oct 13;19(23):6588–6590. doi: 10.1016/j.bmcl.2009.10.028

Scheme 1.

Scheme 1

Synthesis of NLS-HDACi conjugates. Conditions: (a) 4-ethynylaniline, CuI, DIPEA, THF, (b) NaNO2, NaN3, 17.2% HCl(aq), (c) LiOH•H2O, THF/H2O, (d) o-tritylhydroxylamine, EDCI, HOBT, NMM, DMF, (e) alkyne-terminated NLS peptides, CuI, TBTA, DIPEA, THF/DMF, (f) 90:5:5 TFA/TIPS/Phenol