Table 6.
Pathway analysis of candidate biomarkers implicated in cancer. Proteins in bold have been associated with colon cancer.
| Description | Expression ratio range (exact) |
Biological pathways (KEGG Database) |
|---|---|---|
| Transcription elongation factor B (SIII) polypeptide 2 | >9.001 (380) | Renal cell carcinoma |
| Ras related C3 boulinum substrate | >9.001 (13.46) | Adherens junction, Toll like receptor, ALS, Colorectal cancer, renal cell carcinoma. pancreatic cancer, MAPK signaling pathway, Wnt signaling, Axon guidance, VEGF signaling, Focal adhesion, Natural killer cell mediated toxicity, B cell receptor, Fc epsilon RI signaling |
| Platelet derived growth factor | >9.001 (90) |
Colorectal cancer, Glioma. Prostate cancer, Melanoma. MAPK signaling pathway, Calcuim signaling pathway, focal adhesion, Gap |
| Caspase 3, apoptosis related cysteine protease | >9.001 (34.27) | Neurodegenerative disease, MAPK signaling pathway, p53 signaling pathway, apoptosis, Natural killer, Alzhimers, huntington, DRPLA |
| Vcrk sarcom virus CT10 oncogene homolog | >6.001 - 9.0 (6.16 | MAPK signalling pathway, Erb signaling, Focal adhesion, actin cytoskeleton, insulin signaling pathway, renal cell carcinoma |
| Tumor rejection antigen gp96 | >9.001 (26.26) | Prostate cancer |
| Nuclear pore complex associated protein Tpr | >9.001 73.375) | Thyroid cancer |
| Vcrk sarcom virus CT10 oncogene homolog (avian like) | 3.001-6.00 (3.56) | MAPK, Erb, Focal adhesion, actin cytoskeleton, Insulin signaling pathway, renal cell carcinoma. chronic myleoid leukemia |
| Cytochrome C | 3.001 -6.00 (5.5) | p53, apoptosis, Colorectal cancer, Small cell lung cancer |
| Catenin (cadherin associated protein) | 0.33 - 0.99 (1.84) | adherens junction, tight junction, Leukocyte transendothelial |
| Calmodulin | 3.001-6.00 (3.97) | Long-term potentiation, Olfactory transduction, nsulin signaling pathway, nRH signaling pathway, melanogenesis,Huntington’s disease, Glioma. Calcium signaling pathway, Phosphatidylinositol |