Table 2.
Cardiac Mitochondrial Phospholipid Composition in SSM and IFM.
Standard Chow | EPA+DHA | P Value | ||||
---|---|---|---|---|---|---|
Fatty Acid | Sham | Infarct | Sham | Infarct |
Infarct vs. Sham |
EPA+DHA vs. STD |
SSM | ||||||
EPA (C20:5n3) | BQL | BQL | 4.2±0.3‡ | 4.7±0.2‡ | NS | <0.001 |
Palmitic Acid (C16:0) |
12.5±0.8 | 11.3±0.4 | 11.1±0.4† | 10.7±0.1 | NS | 0.035 |
Stearic Acid (C18:0) |
18.6±0.2 | 18.1±0.1 | 17.0±0.3‡ | 17.2±0.1† | NS | <0.001 |
Oleic Acid (C18:1n9) |
15.2±1.1 | 13.0±0.5# | 12.5±0.2† | 12.9±0.3 | NS | NS |
Linoleic Acid (C18:2n6) |
21.6±0.3 | 20.9±0.7 | 21.5±0.4 | 18.4±0.5† | 0.005 | NS |
IFM | ||||||
EPA (C20:5n3) | BQL | BQL | 4.2±0.2‡ | 4.0±0.2‡ | NS | <0.001 |
Palmitic Acid (C16:0) |
10.9±0.5 | 12.0±0.5 | 11.1±0.3 | 12.3±0.3# | 0.007 | NS |
Stearic Acid (C18:0) |
18.2±0.2 | 18.6±0.2 | 17.5±0.1† | 18.0±0.1† | 0.031 | <0.001 |
Oleic Acid (C18:1n9) |
13.7±0.9 | 12.5±1.0 | 11.8±0.2 | 11.2±0.7 | NS | 0.039 |
Linoleic Acid (C18:2n6) |
21.8±0.4 | 21.9±0.8 | 21.8±0.4 | 20.6±0.4 | NS | NS |
Data are expressed as percent of total mitochondrial membrane phospholipid content. Data are the mean±SEM. n=7–8/group.
p<0.05 vs EPA+DHA sham, # p<0.05 vs sham,
p<0.001 vs sham,
p<0.05 vs standard chow,
p<0.001 vs. standard chow sham. The Infarct vs. Sham column represents significant main effects of surgery. The EPA+DHA vs. STD column represents significant main effects of diet. BQL, Below Quantifiable Limits; NS, not significant.