. Author manuscript; available in PMC: 2010 Apr 1.

Published in final edited form as: J Antibiot (Tokyo). 2009 Jul 24;62(10):539–544. doi: 10.1038/ja.2009.66

Table 2.

FIC from Combinational Studies of 4e

Strains of Bacteria	Neomycin	Amikacin	Vancomycin
E. coli ATCC 25922	0.27 – 0.56 (Synergism) ^a	0.38 - 0.53 (Synergism)	ND
S. aureus ATCC 25923	ND	1.0 (Addition or Indifference)	0.53 – 1.5 (Addition or Indifference)
K. pneumoniae ATCC 13883	ND	0.08 - 0.16 (Synergism)	ND
K. pneumoniae ATCC 700603	ND	0.38 - 0.53 (Synergism)	ND
S. aureus ATCC 33591 (MRSA)	ND	0.28 – 0.53 (Synergism)	0.53 – 0.56 (Addition)
P. aeruginosa ATCC 27853	ND	0.38 – 0.50 (Synergism)	ND
E. faecalis ATCC 29212	ND	0.53 – 0.56 (Addition)	0.28 – 0.53 (Synergism)

FIC = [A]/MIC_A + [B]/MIC_B, Synergism: FIC≤0.5; Addition: FIC = 0.5–1.0; Indifference: FIC = 1-4; Antagonism: FIC ≥ 4, ND: Not Determined.