Table 3.
Estimated geometric means (95% CI) of marker concentrations by pack year category in ever smokers
| Pack-years
|
p-value for trend across pack year categories | |||
|---|---|---|---|---|
| <20 | 20–39 | ≥40 | ||
| CD40L plasma, ng/mL | 1.40 (1.22, 1.60) | 1.05 (0.91, 1.22) | 0.88 (0.76, 1.01) | <0.0001 |
| CD40L serum, ng/mL | 2.43 (2.06, 2.86) | 2.66 (2.24, 3.16) | 2.38 (2.00, 2.82) | 0.98 |
| CRP, mg/L | 2.22 (2.00, 2.47) | 2.83 (2.53, 3.16) | 2.76 (2.48, 3.09) | <0.0001 |
| Fibrinogen, mg/dL | 383 (376, 390) | 395 (387, 403) | 394 (387, 402) | 0.003 |
| ICAM-1, ng/mL | 246 (238, 254) | 266 (257, 275) | 263 (254, 271) | <0.0001 |
| IL-6, pg/mL | 3.05 (2.84, 3.27) | 3.51 (3.26, 3.79) | 3.65 (3.39, 3.93) | <0.0001 |
| Isoprostanes, ng/mL | 139 (131, 148) | 162 (152, 172) | 181 (170, 193) | <0.0001 |
| MCP-1, pg/mL | 279 (268, 290) | 293 (281, 305) | 292 (281, 304) | 0.02 |
| MPO, ng/mL | 37.8 (35.5, 40.2) | 36.8 (34.5, 39.4) | 38.5 (36.0, 41.1) | 0.78 |
| P-selectin, ng/mL | 37.7 (36.3, 39.2) | 40.0 (38.4, 41.7) | 40.8 (39.1, 42.4) | 0.0003 |
| TNFR2, pg/mL | 1921 (1864, 1979) | 1978 (1916, 2041) | 1975 (1914, 2038) | 0.07 |
†
Estimated regression coefficients (standard error) for log marker concentrations; the reference group is <20 pack-years, marker concentrations standardized to mean 0, SD 1.