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Immunophenotype of pleomorphic lobular carcinoma in situ. (Original magnification 400X). A. Absence of staining for E-cadherin (note the positive membranous staining in the adjacent normal ducts); B. Strong cytoplasmic staining demonstrated for GCDFP-15; C. Strong expression of androgen receptor; D. Lack of ER expression (note focal nuclear staining in adjacent normal duct); E. HER2 protein overexpression. F. High Ki-67 labeling index.
