. Author manuscript; available in PMC: 2010 Nov 1.

Published in final edited form as: Am J Surg Pathol. 2009 Nov;33(11):1683–1694. doi: 10.1097/PAS.0b013e3181b18a89

TABLE 2.

Summary of Genomic Changes in Lobular Carcinoma In Situ (LCIS) Subtypes

	CLCIS	PLCIS	Non-Apocrine PLCIS	Apocrine PLCIS
Fraction Genome Altered	0.072	0.079	0.054^♦	0.119^*
Fraction Genome Gained	0.041	0.040	0.030^♦	0.056
Fraction Genome Lost	0.031	0.039	0.024^♦	0.063^#
Break Points	6.95	7.905	5.154^♦	12.38^*
Chromosomes with Break Points	3.8	4.19	3.154^♦	5.875^*
Number of Amplifications	0.250	1.952	0.077	5.000^#
Chromosomes with Amplifications	0.050	0.286	0.077	0.625^#
Whole Chromosome Changes	0.150	0.191	0.000^♦	0.500^#

CLCIS, classic LCIS ; PLCIS, pleomorphic LCIS.

^◊

All the numbers represent “mean value” of the genomic changes.

^♦

p< 0.05 apocrine PLCIS vs non apocrine PLCIS

p< 0.06 apocrine PLCIS vs CLCIS

p< 0.05 apocrine PLCIS vs CLCIS