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. Author manuscript; available in PMC: 2009 Nov 26.
Published in final edited form as: Stroke. 2009 Sep 3;40(11):3436–3442. doi: 10.1161/STROKEAHA.109.558015

Table 5.

Details of the Current Study and Previously Published Studies With Replication or Meta-Analyses Post-2005 That Failed to Find an Association With IS

Reference No. Current Study Current Study 17 18 19 20
Subjects (IS/C) 307/324+583/270 710/3751 358/817 3104/4870 (2693/4320)* 1606/2207 (845/1144)* 774/1074 (661/1013)*
Studies Original+replication Original Original 15 (11)* 8 (3)* 7 (6)*
Population European European European Mix Mix Mix
Analysis for each ethnic group European European European Yes Yes Yes
SNPs (gene) 342 (52 genes) 212 (62 genes) 60 (35 genes) 1 (PAI-1) 1 (TNFA) 1 (ITGA2)
Heterogeneity in ORs Yes Yes Yes
Use of covariates Age, sex, AF, D, HT, MI, SM Age, sex, D, HD, HT, SM Age and sex Age, sex, Ch, D, HT, SM No Age, sex, BMI, Ch, D, HT, SM
Use of multiple testing correction No FDR Yes
Other features Age range =45–57 Association in child/Asian
*

White samples.

C indicates control subjects; IS, ischemic stroke; AF, atrial fibrillation; BMI, body mass index; Ch, cholesterol; HD, heart disease; HT, hypertension; MI, myocardial infarction; SM, smoking; D, diabetes; FDR, false discovery rate.