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. Author manuscript; available in PMC: 2010 Dec 14.

Published in final edited form as: Neuroscience. 2009 Sep 6;164(3):918–928. doi: 10.1016/j.neuroscience.2009.08.070

High resolution images using a rapid acquisition, relaxation-enhanced (RARE) pulse sequence were acquired for morphologic reference purposes. Regions of interest were manually outlined and included the entire cross-section of the brain, cortex, dorsal hippocampus, retrosplenial cortex and the thalamus. For FAIR analysis, the recovery curves obtained from each pixel of the global or selective inversion images were numerically fitted to an exponential model and longitudinal recovery rates were then used to calculate the perfusion rate, f (ml/(100g × min)) on a pixelwise basis using the relationship f = λ · (1/τ_NS−1/τ_SS). Areas overlapping large blood vessels or ventricles were removed. A. No significant differences in basal perfusion were found between age-groups (n_adult= 6, n_aged= 12). B. Separation of aged animals by maze performance revealed significantly higher perfusion of dorsal hippocampus in aged impaired (n= 4) when compared to aged intact (n= 8) animals (p= 0.045).

High resolution images using a rapid acquisition, relaxation-enhanced (RARE) pulse sequence were acquired for morphologic reference purposes. Regions of interest were manually outlined and included the entire cross-section of the brain, cortex, dorsal hippocampus, retrosplenial cortex and the thalamus. For FAIR analysis, the recovery curves obtained from each pixel of the global or selective inversion images were numerically fitted to an exponential model and longitudinal recovery rates were then used to calculate the perfusion rate, f (ml/(100g × min)) on a pixelwise basis using the relationship f = λ · (1/τ_NS−1/τ_SS). Areas overlapping large blood vessels or ventricles were removed. A. No significant differences in basal perfusion were found between age-groups (n_adult= 6, n_aged= 12). B. Separation of aged animals by maze performance revealed significantly higher perfusion of dorsal hippocampus in aged impaired (n= 4) when compared to aged intact (n= 8) animals (p= 0.045).