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. Author manuscript; available in PMC: 2010 Nov 24.
Published in final edited form as: Biochemistry. 2009 Nov 24;48(46):10866–10881. doi: 10.1021/bi901476k

Table 4.

Polymerization of pyridone NTP and 4-methylpyridone NTP opposite various bases. Listed is the concentration (μM) of the NTP that gives equal elongation of the ppp(G)3 trinucleotide with that NTP and with GTP

Triphosphate
graphic file with name nihms-154204-t0028.jpg graphic file with name nihms-154204-t0029.jpg
Template graphic file with name nihms-154204-t0030.jpg 520 ± 20 2300 ± 30
graphic file with name nihms-154204-t0031.jpg 70 ± 15 100 ± 30
graphic file with name nihms-154204-t0032.jpg 1300 ± 40 2700 ± 100
graphic file with name nihms-154204-t0033.jpg 660 ± 50 470 ± 40
graphic file with name nihms-154204-t0034.jpg 580 ± 50 810 ± 60
graphic file with name nihms-154204-t0035.jpg 520 ± 30 1100 ± 40
graphic file with name nihms-154204-t0036.jpg 660 ± 20 800 ± 100
graphic file with name nihms-154204-t0037.jpg 3500 ± 100 ND
graphic file with name nihms-154204-t0038.jpg ND ND
graphic file with name nihms-154204-t0039.jpg 700 ± 60 1100 ± 100
graphic file with name nihms-154204-t0040.jpg 610 ± 40 910 ± 80
graphic file with name nihms-154204-t0041.jpg 130 ± 40 1800 ± 200
graphic file with name nihms-154204-t0042.jpg 36 ± 30 70 ± 30
graphic file with name nihms-154204-t0043.jpg ND ND