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. Author manuscript; available in PMC: 2010 Oct 28.
Published in final edited form as: J Am Chem Soc. 2009 Oct 28;131(42):15492–15500. doi: 10.1021/ja9066282

Table 4.

Cyclizations of secondary radical precursor 25 to 26graphic file with name nihms-150630-t0014.jpg

entry substrate er product % yielda er % chirality transfer
1 rac-25a 50/50 rac-26 95 50/50 N/A
2 rac-25b 50/50 rac-26 97 50/50 N/A
3 (+)-25a 98/2 (+)-26 98 98/2 100
4 (−)-25a 99/1 (−)-26 96 98/2 99
5 (+)-25b 100/0 (−)-26 98 99/1 99
6 (−)-25b 100/0 (+)-26 97 99.5/0.5 99.5
a

Yield after isolation by column chromatography on 10% w/w KF/silica gel.