Table 1.

A representative list of affinities (Kd or Ki) for the dopamine (DA) agonists employed in this study at rat or human DA receptor subtypes. Lower values represent higher affinities. Much variation in affinity values is present in the literature, largely depending on experimental parameters, whether both high- and low-affinity receptors are considered, and cell line within which cloned receptors are expressed.

Drug	target receptor	source species	Kd or Ki (nM)	reference
SKF38393 SKF38393	D1 D1	rat human	26.6 45.6	Neumeyer et al, 2003 Yanagawa et al., 1997
SKF38393	D2	rat	9560	Sokoloff et al., 1990
SKF38393	D3	rat	5000	Sokoloff et al., 1990
Quinpirole	D1	rat	>1000	Mottola et al., 2002
Quinpirole Quinpirole	D2 D2A	rat human	4 3.7	Malmberg and Mohell, 1995 Malmberg and Mohell, 1995
Quinpirole	D3	rat	47	Boundy et al., 1993
Quinpirole	D3	human	0.6	Malmberg and Mohell, 1995
Quinpirole	D4.2	human	140-250	Tallman et al., 1997
7-OH-DPAT 7-OH-DPAT	D2 D2	rat human	3.6 125	Gonzalez and Sibley, 1995 Damsma et al., 1993
7-OH-DPAT	D3	rat	0.5	Gonzalez and Sibley, 1995
7-OH-DPAT	D3	human	0.1	Damsma et al., 1993
7-OH-DPAT	D4.2	human	520-1469	Tallman et al., 1997
PD168077	D1	human	4600	Moreland et al., 2004
PD168077	D2	human	1280	Moreland et al., 2004
PD168077	D3	human	2300	Moreland et al., 2004
PD168077	D4	human	11.9	Moreland et al., 2004