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. Author manuscript; available in PMC: 2010 May 12.
Published in final edited form as: Nature. 2009 Nov 1;462(7270):175–181. doi: 10.1038/nature08506

Figure 3. Discovered off-targets network.

Figure 3

Bipartite network where drugs (gold) are linked by gray edges to their known targets (violet) and by red arrows to their discovered off-targets (cyan). Gray edges denote binding at 1 μM or better, where these affinities are known. Node sizes increase with number of incident edges. Target abbreviations: 5-HTx, serotonin receptor type x; 5-HTT, serotonin transporter; β1+, β1 adrenergic agonist; β1-, β1 adrenergic antagonist; β3+, β3 adrenergic agonist; σ1, σ1-receptor; CA, carbonic anhydrase; DAT, dopamine transporter; HIV1RT, HIV-1 reverse transcriptase; hERG, human Ether-a-go-go Related Gene channel; K+, Potassium channel; NET, norepinephrine transporter; NMDA, N-methyl-D-aspartate receptor; VMAT2, vesicular monoamine transporter 2.