Fig. 2.
Baseline urinary PGE-M levels predict disease-free and overall survival in patients with HNSCC. Kaplan Meier survival curves illustrate A. Disease-free survival was significantly lower for patients with high baseline urinary PGE-M values (P<0.01). The two-year disease-free-survival probabilities were estimated to be 46.7% (95% CI = (27.2%, 80.2%)) for patients with high urinary PGE-M, and 87.1% (95% CI= (71.8%, 100%)) for those with low urinary PGE-M. B. Overall survival was significantly lower for patients having high baseline urinary PGE-M values (P=0.01). The three-year probability of survival for patients with high and low baseline urinary PGE-M values was estimated to be 53.3% (95% CI = (33.2%, 85.6%)) and 91.7% (95% CI= (77.3%, 100%)), respectively. The baseline urinary PGE-M values were dichotomized as high and low categories by using the median (16.1 ng/mg creatinine) as the cutoff. This definition of high and low PGE-M categories is used throughout this manuscript.